When you going? I'm going on Friday til Monday. Been before. Depends what you are interested in. Some amazing places to visit, the castle, Charles Bridge, check out the old Jewish cemetary and the Synagogue that has the names of all the Prague Jews that were killed during the Holocaust on the walls.# Plenty of decent beer, I'd recommend Staropraman and Kozel Velkopopovichy. Try and find local type bars rather than the main tourist haunts like the Irish and British bars. The "Herna" bars are pretty good - basically they stay open as long as they have any customers! We were going to go to a match...Slavia Prague were at home but it's been moved to Monday so we won't make it. So if you see someone walking around with BFC wooly hat on it may be me!
Watch your back Pickpocketing and petty theft a major problem. Leave your valuables at home and keep things like wallet, phone, camera out of sight when not in use. Don't be put off - it's a lovely place and worth seeing but of people I know who've been, about one in six has had something stolen whilst there. Forewarned is forearmed.